Our analysis revealed that some of the serum miRNAs were involved in key metabolic, structural, and signaling pathways in NSCLC, including fatty acid biosynthesis (regulated by 3 miRNAs), adherens junctions (regulated by 12 miRNAs), and the p53 pathway (regulated by 13 miRNAs). Here, TP53 is linked to non-small cell lung carcinoma.