The most innovative information from this study is that melatonin, a pineal product, administered by cryopass-laser, a procedure used to actively deliver drugs at the site of action, can reduce the growth of LNCaP tumor cells xenografted in nude mice by affecting SIRT1 expression, which can influence the PGC-1α/PPAR-γ pathway, NF-κB signaling, neovascularization, and proliferation. Here, PPARGC1A is linked to neoplasm.