Some risk factors of R-CDI include immunosuppression [11]; infection with ribotype 027 5, 078, or 244 [11]; a previous history of CDI; severe CDI [4]; gastrointestinal intervention [6]; ≥15 days of acid-suppressive therapy [7]; and serum albumin levels of ˂2.5 g/dL [5,12] (Table 1). This evidence concerns the gene ALB and clostridium difficile infection.