Therefore, we aimed to investigate the C-terminal region of this gene in ocular toxoplasmosis by studying possibly functional, nonsynonymous polymorphisms within a ~7.2 kb long region around Gln460Arg, the most widely investigated SNP in the P2RX7 gene, including the Ala348Thr (rs1718119) variant. Here, P2RX7 is linked to ocular toxoplasmosis.