Purinergic receptors are found on all types of cells in mammalian tissues; P2RX7 KO mice showed increased susceptibility to toxoplasmosis [13], with tissue damage characterized by the impaired production of pro-inflammatory cytokines (IL-12, IL-1β, IFN-γ, and TNF-α) [14]. This evidence concerns the gene P2RX7 and toxoplasmosis.