While more than 25 adhesins, including colonization factor antigens (CFAs) and coli surface antigens (CSs), have been identified from the ETEC strains isolated from diarrhea patients, the strains expressing any of the seven adhesins, CFA/I, CFA/II (CS1, CS2, and CS3), and CFA/IV (CS4, SC5, and CS6), along with enterotoxic heat-stable toxin (STa) and/or heat-labile toxin (LT), are identified as the dominant sources associated with ETEC-associated diarrhea [7,9,10,11], and ETEC strains expressing these seven adhesins tend to be more virulent to cause moderate-to-severe clinical cases [12]. The gene discussed is TBCA; the disease is Diarrhea.