Autophagic activity increases in response to mTOR suppression as part of a physiologic starvation response; decreased autophagy is well established as a feature of cardiac hypertrophy in animals and humans; therefore, activation of autophagy may ameliorate cardiomyopathy in cats, as previously seen in a Mybpc3-targeted knock-in mouse model [8]. Here, MYBPC3 is linked to cardiomyopathy.