On the other hand, our study confirmed that obesity and oxidative stress are closely linked; this was demonstrated by an increased lipid peroxidation, decreased antioxidant enzyme activities, such as SOD, CAT, and GPx, as well as depletions in non-enzymatic antioxidants such as the -SH group and GSH. Here, SOD1 is linked to obesity due to melanocortin 4 receptor deficiency.