By inhibiting the cholinesterase enzymes, including butyrylcholinesterase (BChE) and acetylcholinesterase (AChE), it may be possible to restore ACh levels, thereby improving cholinergic transmission and reducing amyloid aggregation, which could potentially benefit individuals with dementia and Alzheimer’s disease [3,19]. The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.