Serum OPG was independently associated with vascular reactivity dysfunction (odds ratio (OR) = 1.025; 95% confidence interval (CI) = 1.008–1.041; p = 0.003) and poor vascular reactivity index (OR = 1.028, 95% CI = 1.011–1.045, p = 0.001) in HTN patients by logistic regression analysis after being adjusted for certain factors (p < 0.2) of poor vascular reactivity in Table 1, including sex, age, BMI, and eGFR (Table 3). The gene discussed is TNFRSF11B; the disease is hypertensive disorder.