A number of studies have identified a significant association between OPG and endothelial dysfunction, with the study groups recruiting patients with type 2 DM, hyperuricemia, and Hashimoto’s thyroiditis in euthyroid state; in these studies, flow-mediated dilation of the brachial artery via ultrasonography was used for the estimation of endothelial function [25,26,27]. Here, TNFRSF11B is linked to hyperuricemia.