Well-differentiated tumors can be further classified as G1, G2, or G3 neoplasms based on the Ki67 proliferation index and mitotic count (Ki67 < 3% or mitotic count <2 in 2 mm2, Ki67 3–20% or mitotic count 2–20 in 2 mm2, and Ki67 > 20% or mitotic count >20 in 2 mm2, respectively) [6,7,8]. The gene discussed is MKI67; the disease is neoplasm.