A recent analysis of data from the prospective GTH-AH 01/2010 registry [35] showed that anti-rpFVIII antibodies were present in 44% of AHA cases at baseline and were associated with higher titers of antihuman FVIII inhibitor (>100 BU) and lower levels of FVIII (<3.9%). Here, F8 is linked to autoimmune hemolytic anemia.