CCN2 and Nephropathy: We may only speculate that the reduction in our patients may be indicative of the stage of fibrosis—for example, in a nephropathy model in mice, it was shown that the expression level of Ctgf gradually increases over a two-week period and is static afterwards; our results indicate there may be a significant reduction in the expression of this gene following the primary stage of disease development or that the gene can only be expressed for a certain period of time [26].