However, as time passed, progresses and new discoveries shifted the attention to other screening and diagnostic methods of cardiovascular diseases, such as adipose tissues biomarkers (leptin, resistin, adiponectin), proinflammatory status biomarkers (high sensitive C reactive protein—hsCRP), prothrombotic status biomarkers (fibrinogen, plasminogen activator inhibitor-1—PAI-1), abnormal fat tissue distribution (visceral fat, hepatic steatosis), insulin resistance (IR) and hyperinsulinemia (HI) [1,2]. This evidence concerns the gene SERPINE1 and Insulin resistance.