SERPINE1 and hyperinsulinism: However, as time passed, progresses and new discoveries shifted the attention to other screening and diagnostic methods of cardiovascular diseases, such as adipose tissues biomarkers (leptin, resistin, adiponectin), proinflammatory status biomarkers (high sensitive C reactive protein—hsCRP), prothrombotic status biomarkers (fibrinogen, plasminogen activator inhibitor-1—PAI-1), abnormal fat tissue distribution (visceral fat, hepatic steatosis), insulin resistance (IR) and hyperinsulinemia (HI) [1,2].