These soluble factors were proposed as the most promising biomarkers for the early discovery and diagnosis of preeclampsia, and they include placental growth actor (PlGF), soluble fms-like tyrosine kinase-1 (sFLT1), vascular endothelial growth factor (VEGF), and soluble endoglin (sENG) [59]. The gene discussed is PGF; the disease is preeclampsia.