PLK1 and breast cancer: Taking the union of the top-ranked 5 genes with each measure, we obtained 8 cDEGs, including 5 upregulated (COL11A1, COL10A1, CD24, PLK1, UBE2C) and 3 downregulated (PDK4, CD36, ACACB) as the BC-causing hub genes (HubGs) that are displayed in the PPI network (see Figure 3).