To explore candidate drug molecules for BC, we considered 8 HubGs-mediated proteins (COL11A1, COL10A1, CD36, ACACB, CD24, PLK1, UBE2C, and PDK4) and 3 regulatory TF proteins (GATA2, SRF, and FOXC1) as the receptors for docking analysis with 142 candidate drug molecules (ligands) that were collected from different sources (see Table S2). The gene discussed is PLK1; the disease is breast cancer.