In this study, we identified 8 cDEGs (COL11A1, COL10A1, CD36, ACACB, CD24, PLK1, UBE2C, and PDK4) as breast cancer (BC)-causing HubGs from 3 microarrays and one scRNA-seq dataset by the protein-protein interaction (PPI) network analysis of 46 cDEGs. This evidence concerns the gene PLK1 and breast carcinoma.