Elevated levels of natriuretic peptides (i.e., NT-proBNP) [30], the presence of echocardiographic signs of EVLW (i.e., B-lines) [31,32,33,34], systemic venous congestion (i.e., IVC diameter) [35] and RV-arterial uncoupling (i.e., TAPSE/sPAP) [20,36,37] have well-known prognostic value in patients with definite HF diagnosis, regardless of LVEF. The gene discussed is NPPB; the disease is hyperemia.