Classical inflammatory CD14++CD16− monocytes, with high CD192 (also known as CCR2, a chemokine receptor that binds monocyte chemoattractant proteins, MCP-1) expression, due to interleukin-1β (IL-1β) secretion cross the blood–CNS barrier before experimental autoimmune encephalomyelitis onset [44]. Here, CCR2 is linked to experimental autoimmune encephalomyelitis.