In addition, due to insulin resistance or insufficient insulin secretion, DM cannot effectively inhibit fat decomposition, and type 2 diabetes mellitus (T2DM) is often accompanied by obesity, hyperinsulinemia, and dyslipidemia, which ultimately leads to an increase in cholesterol synthesized in the liver, an imbalance in the proportion of cholesterol, bile acid and phospholipid in bile, a saturated cholesterol, and poor water solubility, which increases the risk of forming GBS significantly [7]. Here, INS is linked to type 2 diabetes mellitus.