Furthermore, scientific research has proven that platelet adhesion molecule vWF is upregulated in COVID-19, demonstrating endothelial involvement; however, a disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13), which cleaves high-molecular-weight vWF, is downregulated, resulting in an aberrant ratio of vWF to ADAMTS-13 [68]. This evidence concerns the gene VWF and COVID-19.