Farnesoid X receptor (FXR) is a highly expressed liver receptor (particularly in endothelial, hepatocytes, and Kupffer cells) that has been shown, when activated, to reduce lipogenesis, inflammation, and liver fibrosis in individuals with NAFLD, NASH, or fibrosis and mice fed with a high-fat and high-carbohydrate diet [35,36,37]. This evidence concerns the gene NR1H4 and metabolic dysfunction-associated steatotic liver disease.