Farnesoid X receptor (FXR) is a highly expressed liver receptor (particularly in endothelial, hepatocytes, and Kupffer cells) that has been shown, when activated, to reduce lipogenesis, inflammation, and liver fibrosis in individuals with NAFLD, NASH, or fibrosis and mice fed with a high-fat and high-carbohydrate diet [35,36,37]. Here, NR1H4 is linked to metabolic dysfunction-associated steatohepatitis.