FXR is a highly expressed liver receptor (particularly in endothelial, hepatocytes and Kupffer cells) that has been shown, when activated, to reduce lipogenesis, inflammation, and liver fibrosis in individuals with NAFLD, NASH, or fibrosis and mice fed with a high-fat and high-carbohydrate diet [35,36,37]. The gene discussed is NR1H4; the disease is metabolic dysfunction-associated steatohepatitis.