AFP and hepatocellular carcinoma: The combination of exosomal miR-10b-5p + miR-221-3p + miR-223-3p + miR-21-5p in liver-specific exosomes was shown to perform well in distinguishing HCC from patients with chronic viral hepatitis (AUC: 0.86) with an even higher sensitivity in a combination of miR-10b-5p + miR-221-3p + miR-223-3p (AUC: 0.84) for low AFP-HCC vs. chronic hepatitis/non-HCC patients [55].