The gene set enrichment analysis (GSEA, Supplementary Tables S2 and S3) of gene sets correlated with LAMA4 indicate that LAMA4 is associated with the upregulation of pathways related neurodegenerative diseases such as Parkinson’s and Alzheimer’s, as well as respiratory diseases and ATP synthesis coupled electron transport pathways in both VIS (Figure 1F,G) and SC AT (Supplementary Figure S2A,B). This evidence concerns the gene LAMA4 and Parkinson disease.