According to this study, PRGs risk models were defined with the combination of immune and signaling pathways genes (CASP4, GSDMC, NLRP1, PLCG1, IL-18, CASP1, and NLRP2), among which CASP4, NLRP1, PLCG1, IL-18, and CASP1 are overexpressed in pancreatic cancers. Here, IL18 is linked to familial pancreatic carcinoma.