MAPT and nasopharyngeal carcinoma: The neuropathological features of NPC disease include the loss of Purkinje neurons in the cerebellum, the hyperphosphorylation of tau and the widespread occurrence of neurofibrillary tangles (NFTs), the presence of dendritic and axonal abnormalities, and profound neuroinflammation (activated astrocytes and microglia) [17,18,19,20].