After adjustment for potential cofounders, SEMA3F > 4.7 ng/mL (OR 5.73, 95%CI 1.38–29.76), SEMA7A > 2.0 ng/mL (OR 12.76, 95%CI 2.45- 96.32), admission paO2/FiO2 < 150 (OR 3.76, 95%CI 1.03–14.45) and 4C mortality score > 9 (OR 3.69, 95%CI 1.12–13.42) were associated with the critical disease, while age, sex, comorbidities, CCI, obesity and laboratory parameters such as CRP and LDH were not associated with critical disease in our model (AUC 0.89, 95%CI 0.81–0.96). The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.