Interestingly, we found that the relative and absolute numbers of ‘naïve’ CD8+ T cells were increased in patients with pSS if compared to HC (34.02% (18.86; 42.97) vs. 21.49% (14.94; 28.47) with p = 0.002, and 147 cells/1 μL (62; 226) vs. 69 cells/1 μL (51; 122) with p = 0.002, respectively). This evidence concerns the gene CD8A and peeling skin syndrome.