Comparison of transcriptional activity of the metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinases 1 (TIMP-1) genes in patients with coronary artery disease without heart failure (B) and in patients with coronary artery disease and heart failure (C) by the number of affected coronary arteries are shown in Figure 3 and Figure 4. The gene discussed is TIMP1; the disease is heart failure.