In addition, hyperglycemia can act on the mesenchymal cells, including the periodontal ligament cells, osteoblasts, and osteocytes, and the activation of these cells can dysregulate the expression of the receptor activator of nuclear factor kappa-Β ligand (RANKL) and osteoprotegerin (OPG) via the NF-kB pathway, which is coupled with a reduction in alveolar bone formation and promote periodontal bone loss [16,17,18]. Here, TNFRSF11B is linked to Hyperglycemia.