They found that hepatocarcinogenesis via NAFLD and NASH was induced via DNA methylation of histone H2B type 2-E (HIST2H2BE), heat shock protein family B (small) member 1 (HSPB1), ribosomal protein L30 (RPL30), and aldolase B (ALDOB), as well as the regulation of miR-21 and miR-122. Here, H2BC21 is linked to metabolic dysfunction-associated steatotic liver disease.