RORA and colitis: Kit (encoding c-KIT, which marks a functional subset of ILC2), Rora (encoding RORA, which is required for ILC2 differentiation), Batf (encoding BATF, which is required for ILC2 homeostasis) were found to be upregulated (p-value = 0.016, 0.099, and 0.06, respectively) in the ILCs of KO mice, suggesting that ILC2 was the major responder among ILC groups in our colonic inflammation model (Figure 5).