Kit (encoding c-KIT, which marks a functional subset of ILC2), Rora (encoding RORA, which is required for ILC2 differentiation), Batf (encoding BATF, which is required for ILC2 homeostasis) were found to be upregulated (p-value = 0.016, 0.099, and 0.06, respectively) in the ILCs of KO mice, suggesting that ILC2 was the major responder among ILC groups in our colonic inflammation model (Figure 5). The gene discussed is CCL27; the disease is colitis.