Transcriptome analysis of the APPswe/PS1 L166P and Thy-TAU22 models in mice showed that the APOE, CLU, INPP5D, CD33, PLCG2, SPI1 and FCER1G genes, which are among the AD risk genes, significantly upregulate expression when exposed to beta-amyloid. The gene discussed is PSEN1; the disease is Alzheimer disease.