Suggested in early GWAS, almost all pathways that were critical to AD development, including the Aβ pathway (APP, PSEN1, and PSEN2), inflammatory response (CR1, CD33, MS4A, ABCA7, EPHA1, TREM2 and CLU), lipid metabolism (APOE, SORL1, ABCA7 and CLU) and endocytosis/vesicle transport (BIN1, CD2AP, PICALM, EPHA1 and SORL1) [31,65,66,67,68,69,70,71,72,73]. Here, PICALM is linked to Alzheimer disease.