The increase in IFN-γ producing splenocytes in PBT-treated C57Bl/6 mice and control GCN2-null mice was mirrored in the tumor where total CD8+ T-cells and CD8+/IFN-γ+ T-cells were increased compared with control C57Bl/6 tumor-bearing mice (Figure 2A,B). This evidence concerns the gene EIF2AK4 and neoplasm.