The key roles of these three genes in osteoporosis were verified using multivariate logistic regression, with CTNNB1 (OR = 3.501 × 10−7, p = 0.016) and MITF (OR = 2.475 × 10−14, p = 0.002) as protective factors and TNFSF11 (OR = 9.245 × 1022, p = 0.003) as a risk factor (Figure 4B). The gene discussed is TNFSF11; the disease is osteoporosis.