Evidence in the literature has reported that, at least in the first wave of COVID-19 patients, serum iNOS levels were increased, and iNOS was proposed to be predictive for the COVID-19 outcome [38]; consistently, Karki et al. found that NOS2 expression was significantly upregulated in patients with severe and critical COVID-19 compared to healthy controls [14]. The gene discussed is NOS2; the disease is COVID-19.