It is worth noting that modest levels of RELT protein were detected in the kidney [21] and it is therefore possible that RELT influences hypertension, and the risk of myocardial infarction, through its interaction with the OXSR1 [9] and SPAK [27] kinases, as both of these kinases are targets for the treatment of hypertension based on their ability to regulate ion transporters in the kidney [102]. The gene discussed is RELT; the disease is hypertensive disorder.