ACSL4 and renal fibrosis: Recent studies have shown that activated YAP upregulates the expression of ACSL4, consequently inducing ferroptosis [16,17,18,19,20] However, the role of YAP-mediated modulation of ACSL4-induced ferroptosis in CaOx crystal deposition-induced renal fibrosis remains unexplored, and the underlying mechanism remains unclear.