Our results revealed that expression of CXCL1, CXCL2, CXCL3, and CXCL8 increases in the presence of E6/E7 of HPV16 and 18, are overexpressed in CC biopsies, and that their higher expression is related to a worse prognostic survival in cervical cancer. The gene discussed is CXCL2; the disease is cervical cancer.