MAPK8 and glioblastoma: Potentiation of ROS-mediated U251 cell death by Akt and JNK attenuation observed here is in accordance with the ability of other Akt inhibitors MK-2206 (allosteric), perifosine (alkyl-phospholipid), Akt inhibitor IV (ATP-competitive), and JNK inhibitors AS602801 and SP (ATP-competitive) to increase irradiation-, temozolomide-, gefitinib-, and vincristine-induced death of various GBM cell lines in vitro [9,10,11,16,42,43].