STAT3 and hepatocellular carcinoma: Looking towards bioactive compounds derived from plants that target IL-6 in HCC, including Curcuma phaeocaulis [135], Curcuma aromatica, Polygonum cuspidatum [136], and Silybum marianum [137], it has been shown that curcumin inhibits IL-6-induced JAK/STAT3 signaling cascades through negative feedback, suppressing the development of inflammation in HCC [135].