Several pro-inflammatory cytokines, such as IL-6, TNF, IL-1β, and anti-inflammatory cytokines, such as TGF-α and TGF-β, and also different transcription factors, such as STAT-3 and NF-κβ, together with their signaling pathways, are involved in modulating the development of HCC [97,98,99]. The gene discussed is IL1B; the disease is hepatocellular carcinoma.