Since positive SLNB in thick melanomas automatically increases staging from IIB/IIC to IIIC [29], such patients may be treated with adjuvant systemic therapy, including newer drugs such as immune-checkpoint inhibitors and/or BRAF/MEK inhibitors, which have been shown to improve PFS and OS [41,55,56,57,58,59]. This evidence concerns the gene MAP2K7 and melanoma.