The present study demonstrated a positive correlation between serum activities of CTS D and ASA in cataract patients (r = 0.43, p = 0.039; Figure 3A) and between serum activities of AcP and ASA in healthy controls (r = 0.35, p = 0.046; Figure 3B), which may suggest the nonselective permeation of enzymes from lysosomes. This evidence concerns the gene ARSA and cataract.