To explore whether knockdown of Clec4a expression delivered by oncolytic adenoviruses could induce antitumor immune responses, the CTL activity of mouse splenocytes obtained from MBT-2-tumor bearing mice that had been intratumorally administered with Ad.shDCIR or Ad.LCY for three times was evaluated (Figure 3A). This evidence concerns the gene CLEC4A and neoplasm.