We have previously demonstrated that either Ad.9OC (an Oct4-dependent oncolytic adenovirus driven by nine copies of the ORE) or Ad.LCY (an Oct4 and hypoxia dual-regulated oncolytic adenovirus driven by the HRE/ORE hybrid promoter) exerts oncolytic activities in mice bearing human TCCSUP tumor xenografts or murine MBT-2 syngeneic tumors. Here, POU5F1 is linked to neoplasm.