NOS1 and type 2 diabetes mellitus: We hypothesize that the passive pulsatile shear stress produced by pGz increases the expression of eNOS and nNOS; reduces elevated [Ca2+]i; enhances muscle glucose uptake; alleviates abnormal intracellular ROS generation and calpain activity; and decreases muscle injury, pro-inflammatory cytokines, and iNOS, which in turn may lead to an improvement in strength in a T2D mouse model.