IL11 and systemic sclerosis: IL11 in mammals is supposed to be rooted in its deep evolutionary role for epimorphic appendage regeneration, but this is a double-edged sword, since the same mechanisms can cause organ failure in mammals [18]; for instance, IL11 became a therapeutic target in kidney dysfunction [19], cardiovascular fibrosis [20], idiopathic pulmonary fibrosis [21], systemic sclerosis [22], and non-alcoholic steatohepatitis [23].