The PPI network of NF-κB p65 (RelA) and TNFα by GeneMANIA has been investigated, and the biological processes associated with NF-κB p65 (RelA) and TNFα interaction genes were analyzed with Metascape in order to better understand why elevated expression levels of NF-κB p65 (RelA) and TNFα are significant for the poor prognosis of GBM patients. This evidence concerns the gene NFKB1 and glioblastoma.