The current study aimed to address the following key objectives: (i) analyze the relationship between serum cytokine levels (sCD40L, FLT1, sRAGE, CCL2-MCP1, TNFα, IL-6, IL-18, IL-10, sST2, PIGF, and LIGHT) and the severity of CAD; (ii) investigate specific cytokines potentially associated with a higher risk of severe coronary artery lesions; (iii) identify potential predictors of severe CAD in individuals with suspected CAD. Here, PIGF is linked to coronary artery disorder.