In a systematic review of 65 stroke studies that used the ECASS-2 definitions of HT (n = 17,259), overall pooled HT prevalence was 27% (95% CI 23–30); 32% (95% CI 27%–37%) in those with tPA; and 20% (95% CI 14%–27%) in those without tPA [50]. This evidence concerns the gene PLAT and stroke disorder.