In the studies in non-LA, the approach was differentiated between imaging trials analyzing values of venule caliber, arterial tortuosity, insulin dose, and duration of DM [37], while others associated it with clinical characteristics such as albuminuria [38,39], another focused on morphometric values such as body mass index and waist circumference [40], and another was related to conditions that may be important factors in DR such as psoriasis [41]. The gene discussed is INS; the disease is diabetes mellitus.