Genetic predisposition also plays a role in NAFLD development, and the most common polymorphisms detected in NAFLD patients are genetic variations of transmembrane 6 superfamily member 2 (TM6SF2), patatin-like phospholipase domain-containing protein 3 (PNPLA3), and glucokinase regulatory protein (GCKR) [11]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.