In 35 patients with newly diagnosed moderate to severe OSA, exhaled breath condensates (nitrotyrosine, IL-6, tumor necrosis factor (TNF)-alpha, and 8-isoprostane) and some serum inflammatory biomarkers (nitrotyrosine and 8-isoprostane) decreased after 3-month CPAP therapy (59). The gene discussed is TNF; the disease is obstructive sleep apnea syndrome.